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The FDA has approved these agents based on extensive clinical trial data, but post-marketing surveillance continues to refine our understanding of their safety profile, including gastrointestinal and hepatobiliary effects

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There is also an increasing appreciation that future weight loss drug combination therapies must aim to mitigate nausea and emesis frequently observed with GLP-1 receptor agonists, which can be dose-limiting and reduce patient compliance

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Other drug manufacturers are also facing the same types of actions as a result

In other words, low whole-body BMD was just as strongly associated with prior fractures as low femoral neck or spine BMD in their sample